Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.
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antitumor triterpenoids seaweeds diterpenes Boswellia antioxidant activity antiplasmodial Maytenus chiapensis phenolic derivatives secondary metabolites medicinal applications Malus x domestica pectin cytotoxic activity xanthine oxidase phytochemistry antioxidant Scabiosa sugars sargaquinoic acid pentacyclic triterpenoids analysis antimicrobial and anticancer activity iridoids Tuscany GC-MS (-)-rabdosiin kratom plant defense cembranoids tingenone deoxypodophyllotoxin anticancer pristimerin inflammation boswellic acids plants anti-inflammatory legalization Mitragyna speciosa Ocimum sanctum cordycepin cytotoxic medicine Artemisia species antimicrobial activity lignans Artemisia vachanica Cordyceps militaris frankincense ancient varieties sargahydroquinoic acid Tajikistan antiSMASH ABTS polyphenols therapeutics infectious diseases antibacterial nutraceutics total phenolics LC-MS/MS innate immunity HPLC-PAD sarganaphthoquinoic acid biosynthetic gene clusters DPPH EGCG cneorubenoids PPAR-? bowel diseases amentoflavone molecular docking sargachromenoic acid cannabinoids flavonoids essential oils TCM HPLC-PDA ascorbic acid antioxidants Lamiaceae nanoemulsion malaria therapeutic uses quinonemethide triterpenoids artemisinin natural products biological activities FRAP toxicology defensins Celastraceae cannabis vector control Juniperus analytical determination