Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD's natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.
Efnisorð
thermodynamic modeling molecular dynamics simulation poorly soluble drugs amorphous solid dispersions dissolution enhancement crystallization tendency continuous processing stability milling granulation thermal analysis amorphous ball milling pharmaceutical glass dissolution rebamipide poloxamer classification polyelectrolytes amorphisation self-assembly dissolution rate miscibility bioavailability solubility evaporation mesoporous polyelectrolyte excipient matrix polymer bicaludamide phase diagram Weibull dissolution model spectroscopic techniques anticancer drugs manufacturing methods nucleation molecular complex nanoaggregates enrofloxacin accelerated stability test solubility enhancement amorphous solid dispersion tadalafil process development amorphous polymeric salt Wood’s apparatus hot melt extrusion solid dispersions intrinsic dissolution rate solid dispersion interaction crystallization spray drying characterization ciprofloxacin