Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.
Subjects
tissue engineering microfluidic device ischemia/reperfusion injury syringe pump liver-on-a-chip vacuum chuck epithelial-endothelial interface vessel branching organs-on-chips nanogrooves passive delivery functional neuron imaging organ-on-a-chip lung epithelial cell MEMS drug absorption strain 3D cell culture system mechanical cue multi-culture angiogenesis high-throughput screening fluoroelastomer membranes cell culture paracellular/transcellular transport beating force microfabrication drug hepatotoxicity biomimetic oxidation compression microfluidics surfactant protein PDMS neuronal cell networks neuronal guidance trans-epithelial electrical resistance spheroid array organ-on-a-chip (OOC) biomechanics cell organ-on-chips organ-on-chip stretch shear stress shear flow image-based screening drug metabolism vascularization human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) stress barrier permeability bio-mechanical property cardiac 3D tissue endothelial cell activation organoid silicon lattice light-sheet microscopy integrated pump SH-SY5Y cells thrombolysis 3D cell culture neuronal cells drug efficacy vascularized tumor model