Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.
Subjects
receptor activator of nuclear factor ?B infliximab tripterine triptolide osteoblast tumor necrosis factor-alpha synovial cell anti-arthritis biosimilars Epstein-Barr virus cytokines SOX9 parathyroid hormone nitric oxide rat etanercept angiogenesis glycosylation mitogen activated protein kinase Th9 lymphocytes rheumatoid arthritis IL-6 clodronate bone erosion mesenchymal stem cells collagen-induced arthritis biological gene expression inflammatory arthritis osteoarthritis fraxinellone nuclear factor kappa B messenger RNA inflammation miRNA disease-modifying adipokines WNT glycoprotein 42 miR-199a-5p proliferation next-generation sequencing collagen osteoarthritis (OA) experimental arthritis bone morphogenetic protein TNF-? computational modeling basic research osteoclast therapeutics certolizumab pegol chondrocytes progenitor cells adjuvant arthritis adalimumab triterpenoid sclareol TNF? fibroblast growth factor 2 antibodies osteoblasts molecular pathology Th17 immunology obesity visfatin articular cartilage autoimmune biomarkers celastrol MAPK disease pathways IL1? arthritis bioinformatics anticitrullinated peptide antibodies drug delivery system antagonists shared epitope pathology SMA- and MAD-related protein small-molecule inhibitor transforming growth factor ? mice golimumab spinal fusion antirheumatic drug early osteoarthritis stem cell rheumatoid factor therapeutic antibody bisphosphonate osteoclastogenesis interleukin spondyloarthropathies clinical translation therapy Traditional Chinese medicine chemokines structure cell signaling microRNA